Usichenko E. The state of interferonogenesis and cell immunity in patients with chronic hepatitis C and its correction.

The thesis is devoted to the study of efficacy of endogenic interferon inductor - amyxin in the treatment of patients with chronic hepatitis C. The investigation of peripheral blood lymphocytes, phagocyte activity of neutrophils, cytotoxic activity of NK-cells, receptor sensibility of T-lymphocytes and level of serum IFN and IFN has been carried out; the comparison of results of immunological investigation and clinical efficiency of amyxin therapy in the patients with weak and moderate degree of activity of the pathological process; analysis of some processes of cell-cell-collaboration, interrelation of the amyxin level binding by T-lymphocytes receptors, immune response indices and IFN-state in dependence on quantity of the treatment courses. There was established the increased level of amyxin binding by T-lymphocytes in increased quantity of the treatment courses as well as reversed relation between indices of cytotoxic activity of NK-cells and amyxin binding by T-lymphocytes receptors. The positive influence of amyxin has been ascertained on imbalance of the immune system: increase of the CD3+, CD4+, CD16+ lymphocytes content and immune regulating indices. The efficacy of amyxin in therapy of the patients with chronic hepatitis C increases in prolonged treatment course (6-9 courses).