Denisyuk N. Clinical-neurophysiological characteristic of chronic cerebrovascular pathology in the Chornobyl accident consequences liquidators, in remote period after radiation exposure

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U004689

Applicant for

Specialization

  • 03.00.01 - Радіобіологія

09-11-2006

Specialized Academic Board

Д 26.562.01

State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"

Essay

Clinical-angioneurological peculiarities of chronic cerebrovascular pathology in remote period after radiation exposure to doses ranged from 0.025 to 3.5 Sv were determined on the basis of comprehensive clinical and neurophysiological investigations, as well as qualitative and quantitative estimation of the ultrasonic Dopplerography parameters in 100 men exposed to ionizing radiation as a result of the Chernobyl accident (liquidators; main group), 135 patients with cerebrovascular pathology (comparison group) and 63 healthy men (control group). A target artery (left internal carotid artery/ICA) and the dopplerographic marker of the radiation brain injury in dose range 0.3-3.5 Sv (reduction of the systolic circulation in the left ACI) were revealed. Disturbances of the cerebral hemodynamics in remote period after radiation exposure are etiologically heterogenous; along with general risk factors (age, alcohol abuse, tobacco smoking, somatic pathology) a role of radiation factor was determined at doses exceeded 0.3 Sv. A "dose-effect" relationship was revealed towards thereduction of the systolic circulation in the left ICA in liquidators irradiated by 0.3-3.5 Sv and without bad habits and liver pathology.

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