Gumenyuk N. The peculiarities of immune disorders and their immunocorrection in children with recurring bronchitis

The susceptibility to recurring bronchopulmonary diseases that is inherited both the mother and the father lines averaged 31,8 % children. Congenital genesis for the development of recurring bronchitis (p<0,05) is noted in 55,6 % children. Thymic hyperplasia is found in 56,1 % cases. Studying the function of external respiration the significant decrease in the principal indices from a norm that were indicative of mainly restrictive disorders in children with recurring bronchitis were revealed by us in all the observed children. The significant changes in immune status were obtained: the significantly increased levels of serum IgM and IgA, and s IgA (p<0,05) under insignificant changed level of total IgG especially in children with syndrome of thymic hyperplasia. In children with recurring bronchitis the significant decrease in CD3+, CD4+cells and CD16+ cells and the significantly increased level of CD95 were found determining the indices of cell immunity. It has been demonstrated that disorders of theimmune response in recurring bronchitis is induced at the level of monocytic macrophagal series of the cells that produce the increased number of IL-1, TNF-alfa and start the activation of mainly Tx2 (IL-10).The expediency of using immunotherapy with the preparations of "Ukrain" in a dose of 2,5 mg, the treatment course includes 8 intramuscular injections and "Imunofan" - 1,0 ml of 0,005 % solution as single daily intramuscular injection at the one day interval, the treatment course consisted of 10 injections, was based. The time of children observation was 1 year in both cases. The clinical and immunological effectiveness was demonstrated.