Sobirov B. Clinical experimental research of the influence of the productive air environmental factors of the foundry production on the upper breathing ways

The thesis is devoted to the study of the negative influence of the productive air environmental factors on the upper breathing ways of the foundry production workers and animals under experiment for possible methods correction and definition. This work is based on clinical otolaryngological and laboratory inspection and observation of 120 foundry workers and 30 persons of the control group and also on experimental research of 40 white rats with the use of morphological, histochemical and cytochemical methodic. The defined high level of inflammatory and dystrophic nose and throat mucous process compared with the control group persons and it's direct dependence on service record of workers testifies to its relating to professional factors of the air environmental conditions of the job. The fermented activity in the blood lymphocytes radically decreased and it indicated the disturbance of metabolic processes in them. After the exposition to the air environmental conditions of the foundry production the signs of the chronically inflammatory process with pervascular oedema, the disturbance of covering epithelia structure , the reduction of the amount of plasma cells and the increase of the plasma blasts and tissue basophile were clearly defined in the mucous of the experimental animals. After 10% gel quertzeytine solution inhalation in to the experimental animals the phenomena of chronicall inflammation considerably decreased. The normalization of the ferment activity and morphological mucous structure, that followed, made it possible to recommend these procedures for forun dry workers. The use of gel quertzeytine solution inhalation by the forun dry workers showed its effectiveness, which resulted in the decrease of chronicall inflaminatrory nose and throat mucous processes, firstly of catarrh and hypertrophy, and considerable improvement of the mucous state at atrophic processes.