Maksymcha S. Grounding of applying hyposensibilizing therapy in patients with mandibular fractures

177 patients with the opened mandibular fractures have been investigated in the dissertation. Based on the use of clinical-laboratory investigation methods, the human microbial sensibilization to Staphylococcus functional activity of leucocytes emigrating through the buccal mucous membrane in the oral cavity and activity of cationo proteins etc have been studied. The level of microbial sensibilization in patients with opened mandiblar fractures has been studied. Patients with opened damages of mandible bone, have been faund tu have. The level of microbial sensibilization to Staphylococcus,reliabli increased in on comparison with a norm. The human marked microbial sensibilization has been proved to bi dependent on the state of sanitation of the oral cavity. It has been set that surgical sanitation of the oral cavity in patients with opened mandibular fractures must be conducted in the early terms of medical treatment of the victim. It has been proved scientifically, that the use in complex medical treatment of patients of traditional non-specific hyposensibilizing therapy with antihistaminic preparations of the first generation allows normalizing the level of microbial sensibilization only in persons with mandibular fractures and sanitation oral cavity. If the victim has semidestroyed destroyed teeth, the level of microbial sensibilization by traditional medical treatment is not normalized in spite of the early surgical sanitation of the oral cavity. It has been defined, that posttraumatic inflammatory complications in patients with mandibular fractures are observed only in persons with high indexes of microbial sensibilization. The use of antihistaminic preparations of the second (Cetrin) and third (Telfast) generations with simultaneous surgical sanitation of the oral cavity has been established to normalizing the level of microbial sensibilization and the state of the human local non-specific resistance as well as lowering the number of posttraumatic inflammatory complications.