Pokas O. Microbiological monitoring of the etiology and antibiotic resistance of the pathogens of opportunistic infections

Subject of the research: ethiological structure of opportunistic infections, antibiotic resistance of the pathogens of opportunistic infections. Aim of the research: to conduct microbiological monitoring of the pathogens causing extrahospital and hospital opportunistic infections, to define their antibiotic resistance, and provide recommendations for rational use of antibiotics. Methods of the research: microbiological, statistical. Theoretical and practical results: the research proved the necessity of constant microbiological monitoring of the pathogens causing opportunistic infections and their antibiotic resistance for rational antibiotic therapy; to analyse profiles of antibiotic resistance and to use a unified methodology for establishing sensitivity of microorganisms to antibiotics in order to obtain reliable comparative data on levels of antibiotic resistance. Novelty: the leading pathogens causing extrahospital and hospital opportunistic infections of various localization were discovered, as well as levels and dynamics of their antibiotic resistance. It proved the necessity to analyse profiles of antibiotic resistance taking into account diameters of zones of pathogens growth inhibition around the disks with antibiotics in order to identify homotypic strains. For the first time the specific structure and levels of sensitivity to antimycotics of yeast-like fungi Candida isolated from HIV-infected persons were investigated. The main stages of defining antibiotic resistance of microorganisms by the disk-diffusion methodology were unified. Degree of introduction: the results of the research were implemented in a form of two information letters. Spheres of implementation: Medicine, microboilogy