Karpenko A. Synthesis of annulated heterocyclic compounds of 4-hydrazinoquinazoline derivatives and their biological activity

The dissertation deals with the synthesis of 2-R-[1,2,4]triazolo[1,5-c]quinazolines and 2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones starting from 4-hydrazinoquinazoline, for which were developed preparative methods of its preparation. It was determined structure and investigated physical and chemical properties. It was determined that annulation of quinazoline by 1,2,4-triazole and 1,2,4-triazine in the acid-catalyzed conditions and thermolysis accompanied with the facile Dimroth-like rearrangement. Pharmacological study of 2-R-[1,2,4]triazolo[1,5-с]quinazolines and 2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones reveals a wide spectrum of biological activity, in particular antioxidant, antiradical, hepatoprotective, antibacterial, antifungal and anticancer.