Semeniuta I. Research of informing of cellular models for the preliminary estimation of biological activity of matters

Biological models. Search of informing and sensible biomodels for preliminary estimation of biological activity of matters with the use of experimental and mathematical methods. The formation T-lymphocytes method, elektrophorezis, cluster analysis, method of artificial neuron networks, mathematical treatment of results. The research and estimation of physiologically active substances effects with inverse bioregulatory stereotypes on different experimental biomodels was realized. The high sensitivity of cellular models on the basis of functional reactions of leucocytes to the different physiologically active matters was shown. The degree of informing researched biomodels is determined by using artificial neural networks methods and cluster analysis. The most informative are biomodels on a basis of the immunological reactions - the E-rosette formation of T-lymphocytes, the migration properties of leucocytes and the electrophoretic mobility of the leucocytes. The inhibiting influence of heavy metals cations , as the factors of environmental pollution, on E-rosette formation of lymphocytes, was shown. The algorithm of the effective search and preliminary estimation of biological activity of new substances was developed. Sphere of use - bioorganic chemistry, pharmacology.