Popovich O. Genetic markers in patients with Chronic Hepatitis C

Object - сhronic hepatites С; methods - immun-genetic, clinical, biochemical, molecular-biological, morphological, tools, statistical; novelty - complex definition erythrocyte antigens of blood of system ABO, Rh, P, MN and phenotypes haptoglobin at patients with CHC for the first time is lead; for the first time at patients with CHC distribution of genetic markers of the blood associating a certain genotype of a virus and virus loading is investigated; for the first time at CHC it is certain feature of distribution of genetic markers of blood in groups of patients with different biochemical, morphological activity of a hepatites and distribution of antigenes of blood at patients with different on METAVIR a degree fibrosis is investigated; for the first time the integrated estimation of reliability of updating of risk of occurrence CHC is lead by all investigated factors, the estimation of the importance of separate phenotypes of antigenic systems of blood and uniqueness of their influence on a degree of activity of a hepatites is given; Results - on the basis of an estimation of features of distribution erythrocyte markers and phenotypes haptoglobin blood at patients with CHC representation about existence of individual propensity to occurrence of disease is profound; branch – medicine.