Cherenok S. Calixarenephosphonous acids

The dissertation deals with the functionalization of calixarenes with phosphonic, alfa-hydroxyphosphonic, alfa-aminophosphonic and methylenebisphosphonic fragments at the wide rim of the macrocycle as well as structural, stereochemical, binding and biochemical studies of the compounds obtained. It is established that the calixarene-alfa-hydroxyphosphonates and highly reactive phosphorylated quinonemethydes are intermediates in the synthesis of the calixarenebisphosphonates. It was shown the amphiphilic calixarenephosphonic acids and their salts form nanoparticles (d=150-1200 nm) in aqueous solutions and on the air-water interphase. Binding properties of calixarene-а-hydroxyphosphonic acids towards aminoacids and dipeptides were studied. Calixareneaminomethylphosphonic acids and calixarenemethylenebisphosphonic acids are efficient inhibitors of alkali phosphatases.