Iurko K. Bifi-form influence on colon microbiocenosis state and blood serum metal-dependent enzymes activity in patients on shigellosis

Changes of colon microbiocenosis qualitative and quantitative composition, which are accompanied by the reliable decline of Bifido- and Lactobacterium amount and increase of conditionally pathogenic microorganisms amount (Eschericheae with haemolytic properties, Staphylococcuss and fungi of the genus Candida) are marked at shigellosis. Study of microelements content in the blood serum of patients with acute shigellosis is characterized by the decline of zinc and iron amount, but substantial increase of copper level. It is discovered that in acute period of shigellosis there are the increase of ceruloplasmin and haptoglobin contents at the patients of all groups. Contents of catalase and superoxide dismutase were also increased at mild and moderate state that testifies to activating of the organism antioxidant system, and are reduced at severe state of shigellosis, that talks about exhausting of antioxidant defense. Link (p<0,05) between disease state, intensity of colon microflora dysbiotic changes andmaintenance of microelements and metal-dependent enzymes in the blood serum of patients with shigellosis is established. It is revealed that complex therapy of acute shigellosis with the use of Bifi-form promote more early regression of disease clinical symptoms and characterized by positive influence on intestinal microflora, content of blood serum microelements and metal-dependent enzymes.