Shelyuk O. Mechanokinetics of process contraction-relaxation of smooth muscles rats caecum and the influence of sodium pump inhibitors on it

The mechanokinetics of contraction-relaxation of circular smooth muscles rats caecum and influence of inhibitions of Na+,K+-АTPase (ouabain and the some calixarene) on it were studied in the dissertation The isometrical contractions of multi-cellular smooth muscles preparations evoked by high-potassium solution and acetylcholine were analyzed for the study of dy-namic properties of contractile process. The perspectives of the use of mechanokinetical model of smooth muscles contraction-relaxation was shown for quantitative description with the pur-pose of comparison of information, obtained in presence of dif-ferent effectors. The influence of different physical and chemical factors (giposodium solution, organic blockers of L-type Ca2+-channels, temperature) was also studied on the mechanokinetical parameters of caecum contractions. In the researches of concen-tration dependences of acetylcholine-evoked contractions in pres-ence inhibitors of voltage-activated Ca2+-channels (nifedipine and D600) it wasshown certain higher efficiency of nifedipine. Were studied the comparative influence of Na+,K+-АTPase inhibitors (ouabain and calixarenes С99, С107) on the kinetics of caecum smooth muscles; it is established, that on some mechanokinetical parameters (amplitude, normalized speed of contraction) action of calixarenes like to caused natural inhibitor of sodium pump ouabain. The fragment of calixarene С107 (M3) shown ability to inhibition of acetylcholine-evoked contractions, however consid-erably more weak in comparison with C107.