Pokryshko O. A-bacterinum influence degree on colonization and adhesion properties of clinically significant members of skin microbiocenosis

The thesis is devoted to the problem of studying colonization and adhesive properties of diabetic foot microbiocenosis in patients with diabetes mellitus. Influence of probiotic A-bacterinum was studied on microbal community of foot skin. The diabetic foot skin colonization by staphyloccocci, micrococci, corynebacteria, bacilli, streptococci, pseudomonas, and enterobacteria had been confirmed. The degree of foot skin microbiocenosis disbiosis according to severity of diabetic foot syndrome has been revealed. The application of A-bacterinum influences on a foot skin microbiocenosis in patients with diabetes mellitus reducing a colonizational level bacterial species, causing decrease of S. aureus, Streptococcus, Enterobacteriaceae quantity. In more cases, staphyloccocci, micrococci had high or middle adhesiveness, bacilli and corynebacteria had low adhesive activity or had no it. The obtain finding have been indicated the changes of bacterial adhesive activity according to pyonecrotic lesion of diabeticfoot severity degree. The adhesiveness of staphylococci, micrococci and corynebacteria has diminished, whereas adhesive properties of Bacillus spp. has increased on the contrary. The antibiotic susceptibility of foot skin microflora has been studied. Microorganisms were sensitive to cephalosporins, tetracycline. Bacteria were resistent to penicillin and lincomycine. Staphylococcus populations were the most resistant to antibiotics.