Annenkov O. Dynamics of psychopathological, pathopsychological and neurochemical changes under the conditions of the paranoid schizophrenia in the process of treatment.

This work presents the data received in the process of complex clinical psychopathological, pathopsychological and neurochemical study. This data reflects the effectiveness of the treatment of patients suffering of different types of paranoid schizophrenia with atypical antipsychotics. There were discovered the law-like effects of the dynamics of positive and negative psychopathological symptomatics while treating with rispolept alone or simultaneously with azaleptine. There were found the side effects caused by using various therapeutical strategies. Also there was analyzed the dynamics of pathopsychological disturbances of the functions of thinking, memory, attention, emotional sphere and self-evaluation in the process of the therapy. There were shown the peculiarities of the state of catecholamineergic, serotoninergic systems in the process of treatment. Utilized approach to evaluation of the effectiveness of the treatment called for the selection of differentiated means of the therapy for paranoidschizophrenia. Key words: paranoid schizophrenia, psychopathological symptoms, pathopsychological characteristics, neurochemical disturbances, dynamics, treatment.