Оkhrimenko N. State of acid-base balance and gas content of coronary blood under insulin modulation of heart activity in healthy animals and animals with experimental diabetes

Object: the functional state of cardiovascular system, acid-base balance (ABB) and gas composition of coronary blood under physiological conditions and experimental diabetes (ED). Purpose of research is to determine the peculiarities of ABB changes and gas composition of coronary blood under insulin modulation of cardiac functional state, as well as the tone of coronary vessels in healthy animals and animals with ED. Methods of research and the equipment: gas-analytical, physiological, biochemical methods: gas-analyzer "Corning-166", X-ray apparatus TUR-DE-16, polygraph "Mingograph-81". Theoretical and practical results: based on an analysis of relationships between the level of insulin supply, the character of ABB, gas composition of coronary blood and functional state of cardiovascular system changes, data were received, that extend the knowledge of pathogenetic mechanisms of metabolic factors' participation in the evolution of diabetic cardiovascular complications, which may be used in healthcare practice when developing new approaches to the treatment of diabetic lesions of heart and vessels. Novelty: it was first shown that insulin-induced shifts in ABB, gas composition of coronary blood in animals with ED, as well as in healthy animals, are caused by changes in blood supply and myocardial function due to ?-adrenergic, M-cholinergic and endothelial NO-dependent mechanisms of cardiac function regulation, coronary and systemic circulation interaction at receptor and postreceptor levels. Degree of introduction: the results may be used as a theoretical ground for identification of pathogenesis deterioration of heart and vessel function in patients with diabetes mellitus and elaboration of new methods of treatment. Area of using: endocrinology, cardiology.