Lipatnikova G. Clinical pathogenic peculiarities and treatment of peptic ulcer diseases in combination with irritable bowel syndrome

The dissertation is devoted to improvement of the quality of diagnosis to raise the treatment effectiveness of with peptic ulcer diseases accompanied by irritation bowel syndrome. Complex investigations (clinical, biochemical, cytological, cytochemical, immunologic parameters, ultrasonographic, fibrogastroscopy with biopsy, histological screening of helicobacter infection, determine the condition of the microlandscape of the intestines) are carried out on patients with combination pathology. The interrelationship between these parameters and prevalence of peptic ulcer is described. Patients with this combined pathology, have changes in cytokines level and inflammatory activity. As a result of the complex treatment of the imunofan, it is established, that in this fundamental group of patients, a positive dynamics of immunologic parameters with breakdowns in a cellular part of immunity took place. During this time, comparative group of patients with of breakdown in immunologic parameters and lance had animmunodeficiency condition, were used as controls. Repeated investigations conducted on these patients, after treatment with imunofan has shown regularity the influence exerted on the concentration of proinflammatory (TNF, ІL1, IL2) and antiinflammatory (IL4) mediators. Thus, used of imunofan in the complex treatment of aggravations peptic ulcer diseases accompanied by irritation bowel syndrome, promotes improvement immunologic parameters: liquidations Т-lymfopenia and disbalance fundamental regularity cells that is clinically shown by faster disappearance of the symptoms of aggravation, arrival of proof remission and the overall improvement in the general condition of patients.