Povstyanoy V. Interaction of the cyclic amidrazons containing unsubstituted exocyclic hydrazine group with 1,3-di(tri)electrophils

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U002711

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

23-05-2008

Specialized Academic Board

Д 41.219.02

Essay

The work is dedicated to the research of the regioselectivity processes of the new azole-azine cycle formation in the reactions of condensation of the cyclic amidrazons containing unsubstituted exocyclic hydrazine group (CA) with 1,3 bielectrophils (diverse in their nature). The research refers to the relevant development of prospective sigle-reactor methods of the synthesis of substituted pyrazole-1-il- cyclic amidrazons, the condensed derivatives of dihydro-4-oxo-1,2,4-triazine cyclic amidrazons and the annelated isomeric 2-arylfuro[3,2-c]- and [2,3-c]-1,2,4- triazine cyclic amidrazons, that are potentially suitable for the requirement of screening of biologically active substances by combinatorial chemistry. It has been established that the emanating cyclic amidrazons as well as their acquired hydrazine(hydrazide) derivatives are the suitable syntons in the processes of the intramolecular heterocyclization, that is being fulfilled just in one of two revealed routs: by means of the exopyrazole cycleformation with the creation of the pyrazole-il-cyclic amidrazons of the biphenyl type or the closing of dihydro-4-oxo-1,2,4- triazine ring which is annelated with the nuclei of the emanating basic alloy. The factors influencing on the condensation route have been analysed and the mechanism of a intramolecular heterocyclization process was proposed.

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