Kushch I. Clinical evaluation of breath analysis using TCNQ-derivatives based sensors in adolescents with gastroduodenal pathology

This study is aimed in developing new alternative methods of noninvasive diagnostics using breath gas analysis in contemporary gastroenterology. The response of new TCNQ-derivatives-based sensors for the action of breath gas of adolescents with chronic gastroduodenal pathology has been investigated. We found that the sensor's response curves have distinctive features of diagnostic importance in patients under study which can be applied as a new breath test. It has been shown that the sensors' response depends on presence of Helicobacter pylori and varies in patients with different severity of Helicobacter-associated gastritis and duodenal ulcer. The innovative approach in diagnostics of helicobacteriosis, i.e., recognition of Helicobacter pylori by non urease products of its metabolism has been proposed and realized. Linear correlation between of intragastric acidity level and one of parameters of response curves has been found. The mathematical model to determine state of intragastric acidity basing on the results of breath testing has been created. The concurrent diseases of hepatobiliary system did not influence the results of the new breath test in the investigated cohort. Thus, the results of the study can be implemented into clinical setting as a new breath test for noninvasive detection and monitoring of gastric acidity, HР infection and helicobacter-associated destructive or inflammatory changes of gastric and duodenal mucosa. Key words: breath gas, sensors, breath test, chronic gastroduodenal pathology, Helicobacter pylori, gastric acidity, adolescents.