Yevko O. Functional thyroid and adrenal disorders in hematological pediatric patiets survived after the Chernobyl NPP accident in remote period upon the accident.

Thesis provides the new solution of scientific issue of scientific issue of thyroid and adrenal function both with hematological patology (i.e. anemia, leukemoid response, leukemia) course in children exposed to radiation and non-radiation factors of the Chernobyl NPP accident in remote period. Proposed solution is based on the assay of pituitary thyrotropin. thyroid hormones and cortisol in serum. Hematological malignansy risks are calculated. Significant elevation of serum thyrotropin is registered in 14,3 % of children survived after the Chernobyl accident and having favorable course of hematological patology (PDA, leukemoid response) vs. 0,7 % in kids having no hemopoetic abnormalities. Hyperthyrotropinemia was found more often in ALL patients (20,3 %). Initial indices of serum cortisol content were decreased along with more severe disease course in some patients suffering ALL in the stage of full-scaled clinical pattern (21,2 %). There was no dependence on 137 Cs soil contamination, absorded radiation dose values and serum hormone content. Absorbed internal radiation doses on the red bone marrow and bone surface cells in ALL were in average 5,37 mSv and 5,58 mSv respectively making no impact on the life span and disease course. Serum TSH and cortisol levels, frequent respiratory diseases with lymphadenopathy, increased body mass at birth and endocrine diseases in relatives were introduced as extra criteria to form the risk groups in children exposed to radiation and non-radiation factors of the Chernobyl accident. ALL incidence is increased in kids having hypocortisolemia (RR 1,09 Di 0,97=1,23).