Letyago A. The state of nicrocirculation and vegetative nervous system by osteoarhtrosis in adolescents against the background of hypermobility syndrome

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U004156

Thesis Registration Form

0408U004156.pdf

Applicant for

Specialization

  • 14.01.10 - Педіатрія

24-09-2008

Specialized Academic Board

Д64.609.02

Essay

The thesis contains a novel solution as regards the issues of osteoarthrosis (OA) early diagnosis against the background of hypermobility syndrome (HS) in adolescents, aged 15-18. The main manifestation of OA clinical symptoms depending on its duration and patient's gender have been studied. Some personality characteristics have been investigated with determining the type of attitude to the disease, and the character accentuations, neurotism, and the emotional stress level as correlated with the disease have been estimated. The results of studying the microcirculation system state with estimation of lesions in vascular, intravascular and perivascular links of microcirculation have been presented in the thesis. Parameters of tissue perfusion obtained by the laser doppler flowmetry have been analyzed. A connection of disorders in microcirculation with immunologic findings for inflammation (IL-1, IL-6 and TNF) and with the state of clinical immunity has been outlined. The thesis presents the peculiaritiesin vegetative regulation in adolescents with OA and in patient with HS without OA signs. Criteria of OA diagnosis in adolescents against the background of HS, as well as differential and diagnostic criteria of the disease have been described. Key words: adolescents, osteoarthrosis, hypermobility syndrome, microcirculation, vegetative nervous system, personality characteristics, inflammation

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Files

АВТОРЕФЕРАТ Летяго Г.В-aref.doc

ДИСЕРТАЦІЯ Летяго Г.В-01-ТИТУЛ.doc

ДИСЕРТАЦІЯ Летяго Г.В-02 - ЗМІСТ.doc

ДИСЕРТАЦІЯ Летяго Г.В-03 - ПЕРЕЛІК УМОВНИХ ПОЗНАЧЕНЬ.doc

ДИСЕРТАЦІЯ Летяго Г.В-04 -ВСТУП.doc

ДИСЕРТАЦІЯ Летяго Г.В-05 - РОДІЛ 1- ОГЛЯД ЛІТЕРАТУРИ.doc

ДИСЕРТАЦІЯ Летяго Г.В-06 - РОЗДІЛ2- МАТЕРІАЛИ ТА МЕТОДИ.doc

ДИСЕРТАЦІЯ Летяго Г.В-07 - РОЗДІЛ 3 - КЛІНІКА.doc

ДИСЕРТАЦІЯ Летяго Г.В-08 - РОЗДІЛ 4 - ПСИХОЛОГІЯ.doc

ДИСЕРТАЦІЯ Летяго Г.В-09 - РОЗДІЛ 5 - МІКРОЦИРКУЛЯЦІЯ.doc

ДИСЕРТАЦІЯ Летяго Г.В-10 - РОЗДІЛ 6 - ВНС.doc

ДИСЕРТАЦІЯ Летяго Г.В-11- РОЗДІЛ 7 - ВЗАЄМОЗВЯЗКИ.doc

ДИСЕРТАЦІЯ Летяго Г.В-12 - РОЗДІЛ 8 - ОБГОВОРЕННЯ РЕЗУЛЬТАТІВ.doc

ДИСЕРТАЦІЯ Летяго Г.В-13-ВИСНОВКИ.doc

ДИСЕРТАЦІЯ Летяго Г.В-14-ПРАКТИЧНІ РЕКОМЕНДАЦІЇ.doc

ДИСЕРТАЦІЯ Летяго Г.В-15 - СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ.doc

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