Sokhan A. Clinic immunologic data and their correction in patients with herpesviral meningoencephalitis.

Condition of clinical, biochemical, immunologic data and interferonogenesis in 82 patients with herpesvirus meningoencephalitis of severe and moderate course in dynamic disease was studied. Significant decreased quantity CD4+ cell was revealed in patents with severe clinical course in acute period. Significant dependence of interleukins concentration in blood serum and cerebra-spinal liquid of patients with disease severity was proved. More pronounced disturbances observed in acute period of herpesvirus meningoencephalitis. Concentration TNF-a was in blood in patients with moderate course. Level of IL-4 and IL-10 more increased in patients with severe course (p<0.05). In recovery period content of these cytokines in blood decreased in all groups but increased in comparison with indexes of control group (p<0.05). Increased level of TNF-a and INF-g was the most significant in liquor of patient with severe disease course (p<0.05). In acute herpesvirus meningoencephalitis TNF-a and INF-g synthesized in CNSdue to level of these cytokines higher in liquor then in blood serum (p<0.05). Investigation of cytokines level IL-1, TNF- a, INF- g, which are produced by Th-1 lymphocytes and natural antagonists IL-4, IL-10 synthesized by Th-2 lymphocytes showed prevalence of anti-inflammatory cytokines under regulatory cytokines. Results of condition of immune response and interferonogenesis can be use as prognostic criteria of course in case of herpesvirus lesion of CNS. Therapeutic efficacy and influence on immune response indexes medication Amixin IC in application in complex treatment of patients with moderate course of herpesvirus meningoencephalitis was estimated.