Sabkovs'ka K. Optimization of treatment of patients with hypertension diseases with accompanying irritable bowel syndrome

The thesis is devoted to optimization of treatment of hypertension illness with accompanying irritable bowel syndrome. The results of examination of 145 patients with considered hypertension disease with accompanying irritable bowel syndrome witness about peculiarities of clinical current of comorbine pathology (the domination of cordial and vegetovessel display, increase of level of clinical features of digestive system). Higher day figures and indexes of load by systolic and diastolic pressure, mainly due to night figures, were observed among the majority of the examined patients. The presence of endotelin dysfunction with probable increase of containing of endoteline-1 in blood and deficit of stable metabolic components of nitric oxide, essential disballance of metabolic homeostasis with activization of processes of lipooxidation on the background of disballance of activity of ferments of antioxidant defense and reduction of quantity of renewed glutathione in blood, disballance of cytokine of bloodthat was characterized by essential increase of concentration of inflammatory cytokine (IL- 1?, IL-6) and by moderate increase of quantity of anti inflammatory (IL - 4) cytokine in blood were diagnosed. The necessity of wing of combination of glutargyne and livencyale forte in complex treatment of patients with hypertension disease with accompanying irritable bowel syndrome was patogenetychally explained. The intensification of renewing of metabolic indexes, reduction of endotelin dysfunction and avoiding of disballance between inflammatory and anti-inflammatory cytokines were observed.