Skrotska O. Antiviral activity of a molecular complex containing RNA and tilorone against experimental herpes simplex virus infection.

Dissertation deals with investigations concerning the effect of a molecular complex containing RNA and tilorone (MC) on the course of the infection caused by herpes simplex virus type I in in vitro and in vivo. Antiherpetic MC activity non-dependent on the IFN system effect has been demonstrated in in vitro conditions in Vero cell culture. The MC chemiotherapeutic index in HSV-1 infected Vero cell culture is 324 - a fact permitting to research this complex as a promising antiherpetic drug. The MC is shown to decrease the lethality level of infected animals by 80 %. The defense coefficient of the MC for experimental herpetic meningoencephalomyelitis is 5, the affectivity index heaving been reached up to 80. The author has detected the MC ability to influence on the characteristics of cytokine status of infected animals. The MC use in experimental herpetic meningoencephalomyelitis has led to the activation of macrophagal immunity link.