Shablykin O. Synthesis of 5-amino- and 5-hydrazino-1,3-oxazoles derivatives with potential bioregulator activity

Reactivity acylamyno-3,3-dichloroacrylonitriles and related with them ciano-1,3-оxazoles. Development convenient synthesis of new types of derivatives 5-amino- and 5-hydrazino-1,3-oxazoles which are perspective for searches of bioregulators of different action. Chemical synthesis, IR-spectroscopy, mass-spectrometry, X-ray research. A great extended cyclocondensation possibilities of 2-acylamino-3,3-dichloroacrylonitriles with nitrogen bases and amino acids was realized. Useful methods for introduction of various hetaryl substitutents in fourth and fifth positions of oxazole ring was developed. Derivatives of new heterocyclic system, in which oxazole ring was annelated to 1,2-dihydro-1,3,2-diazaphosphoninic fragment are synthesized. The path of complicated interaction of N2-acyl derivatives of 5-hydrazino-4-cyano-1,3-oxazoles with Lawessons reagent was determined. A number of new derivatives of various azaheterocycles were obtained. High pharmacological properties of synthesized compounds and in some cases their biological activity was confirmed. Sphere of use - bioorganic and organic chemistry.