Muraviova I. Hormonal-biochemical disorders in clean-up workers of consequences of the Chernobyl accident in remote period of exposure to ionizing radiation at metabolic syndrome

The study involved 100 clean-up workers of the consequences of the Chernobyl accident with metabolic syndrome divided into 2 subgroups: 50 patients with acute radiation sickness (ARS) exposed to doses over 1.0 Gy, 50 patients exposed to doses 0.3-0.9 Sv; 37 patients with metabolic syndrome in control group not exposed to ionizing radiation. Serum amino-terminal propeptide (PINP) and carboxy-terminal telopeptide of collagen type I (ICTP) levels were greater in exposed patients with ARS having doses over 1.0 Gy than in those without. Linear dependence was presented between radiation dose and serum PINP and ICTP level in the first subgroups. This observation may help explain the complex changes in extracellular matrix after radiation impact and may suggest new ways for diagnostic and therapeutic interventions. Systematic Coronary Risk Evaluation (SCORE) was elevated in clean-up workers of the consequences of the Chernobyl accident with left ventricular hypertrophy (LVH) and correlated with PINP at patients with ARS in those with concentric LVH. These findings suggest that changes of collagen I type turnover in exposed persons may be involved in the enhancement of myocardial fibrosis that accompanies the development of systematic coronary risk.