Fedoseeva O. Morphofunctional features of lymphoid structures of different departments of human colon in ontogenesis.

Dissertation is devoted the study of morphofunctional features of lymphoid structures of different departments of human colon in different periods of ontogenesis. For the first time was formulated conception of development of lymphoid structures of colon, which are characterized the intensive flow of important morphogenic processes in ontogenesis. The morphofunctional indexes of lymphoid structures of human colon are set in an age-dependent aspect. The morphofunctional criterions of structural components of lymphoid formations of different departments of human colon are developed. With a help of macro-, microscopic, histological, immunohistochemical methods of research conformity to appropriateness of dynamics of amount is set, sizes, form, zonality, distributing of PNA+, SBA+, CD3+, CD20+ of lymphocytes and cellular composition of lymphoepithelial and perivascular nodules of different departments of human colon. Set intertissue connections of lymphoid formations of colon, the deep study of which opens new directions in development of fundamental researches in ontogenesis of local immune defence of human colon. The high degree of expression of markers of CD 34 in prenatal and postnatal ontogenesis in lymphoid formations of different departments of human colon testifies to the different degree of development of the system of microcirculation of lymphoid formations of colon.