Bondarenko T. Influence of prolactin on testosteronedependent processes in the prostate

Investigation object: functional relationships prolactin and testosterone in the regulation of intracellular processes in prostate. Purpose: to examine the influence of prolactin on testosterondependent synthesis RNA, nuclear and cytoplasmic proteins in the prostate under conditions of intact organism and in the violation of the structural-functional relationships in the hypophysial-gonad complex. Methods: physiological, pathophysiological, biochemical, radioimmunological, histological, statistical. It was found that, fluctuations of a prolactin level in intact organism animals can cause both increase, and decrease of a level of concentration testosterone have been established. Testosterone also has influence upon the prolactin concentration: prolactin concentration is increased in the lowered testosterone level, and exerts prolactin level decrease in the elevated testosterone level. Elevated prolactin and testosterone levels in blood plasma provide an increase mass of prostate both in intact organismand in disrupted hypophys-gonad complex. In this condition hyperprolactinemia stimulated the testosterone action on the above mention parameters. Prolactin and testosterone exhibit a dominant effect on the same macromolecular processes in prostate cells: synthesis of nucleinic acids, synthesis of the nuclear and the cytoplasmic proteins. However, the degree and a vector of influence of the hormones on above-mention processes are different and depend on a state of hormonal homeostasis. Field of application: in Experimental and Clinical Endocrinology in the creation of new approaches to treatment and prevention of hypertrophy and hyperplasia of the prostate. Results thesis can be recommended for inclusion in a lecture course on endocrinology of higher education.