Polishchuk P. Affinity of 5-HT1A receptors to their ligands. QSAR analysis with the aim of hierarchical system of models on the basis of simplex representation of molecular structure

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U001661

Thesis Registration Form

0409U001661.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

27-03-2009

Specialized Academic Board

Д 41.219.02

Essay

The work is dedicated to the research of influence of arylpiperazine derivatives on their affinity to 5-HT1A receptors with the aim to creation of new potent anxiolytics. All researches have been made in the framework of hierarchical system of QSAR models on the basis of simplex representation of molecular structure. Structural factors which had a major impact on affinity of ligands to 5-HT1A receptors have been determined. Series of perspective ligands have been constructed. Some of these ligands can have useful pharmacological effects (anxiolytic, antipsychotic, antidepressant) in addition to their high affinity to 5-HT1A receptors.

Read more

Files

aref1.doc

Similar theses

0521U101865

Igor I. Gerus

Synthesis of new fluorine-containing bioactive compounds based on β- alkoxyvinyl polyfluoroalkyl ketones

0521U101758

Frasinyuk Mykhaylo Serhiyovych

Chemical design based on isoflavonoids, aurones and coumarins of biologically active compounds

0521U101359

Metelytsia Larisa O.

In silico and in vitro evaluation of azole derivatives antimicrobial activity against resistant strains of fungal and bacterial cultures

0421U101808

Kuziv Iaroslav B

Covalent labeling of biomolecules with the reagents based on 3-hetarylcoumarins

0421U101809

Feskov Illia O

1,3-Substituted cyclobutanecarboxylic acids as structural fragments for isosteric replacements