Balannik Z. Condition T- and B-system of immunity at patients with infective endocarditis before and after surgical correction of the

In dissertational work was presented results of studying of parameters Т-and B-system of immunity at patients withinfective endocarditis (IE) before and after surgical treatment of the strucked valves of heart, results of studying of a conditionlipid oxidation and antioxidant activity, a level of intoxication in patients. It was revealed a reorganization of T-system of immunityin patients with IE, which characterize for infectious process which is accompanied by reduction of T-lymphocytes (CD3+); theexpressed anti-infectious protection is accompanied by activation of natural killers (СD16+) and activated lymphocytes СD25+(with RIL-2) as reply to massive receipt of infectious antigenes. It was improved the diagnostics method of an infectiveendocarditis caused by staphylococci, which allowed to reduce time of revealing of the activator of disease till 4-5 hours(instead of 4-5 day by means of microbiological researches) as a result of application of a staphylococcal infection definitiontechnique in neutrofils fractions of leukocytes by means of a method of fluorescing antibodies (МFА). It was offered to considerin treatment of patients with IE condition Т-and В-immune system and at gross changes of parameters cellular and humoralimmune answer are shown immune correction preparations that should be spent in view of individual lymphocytes sensitivityby patients to them. To reduce a level of intoxication at gross changes of metabolic processes parameters (levels the POL,АОА, alpha1-IP, the activity of ceruloplasmin in blood serum of patients with infective endocarditis) it is necessary to enterantioxidant preparations (ceruloplasmin) in the scheme of treatment.