Mazur O. Study of the cancer glycopeptide vaccines antitumor efficacy on the experimental models of intracranial malignant growth

Thesis is devoted to cancer glycopeptide vaccines development and studying of their antitumor effect of on the experimental models of intracranial malignant growth. Using brain tumor tissues cancer glycopeptide vaccines (СGV) were prepared and characterized. It was shown that СGV is a highly purified glycopeptide, which is prepared using tumor tissues proteolytic hydrolysis following gradient fraccionation. СGV possesses immunomodulating and antitumor activity, as was demonstrated in experiments in vivo. Vaccines prepared on the basis of cancer cells glycopeptides demonstrated antitumor efficacy in experimental models of malignant growth including glioma 101.8, melanoma В16). СGV application safety and absence of overall toxicity, local irritation, allergic actions have been shown. Composition from the water soluble vitamins С and К3 for potentiation of antitumor effect of СGV, which can be used for activating the systems of antitumor defence and stimulation of immune respons, was first offered.