Marusyk H. Microbiocenosis of the mucous membrane of the palatine tonsils and the large intestinal cavity in the patients with acute tonsillites

Object of the research: patients with lacunar, follicular and catarrhal tonsillites. The objective of the research: to examine the specific composition and population level of the microflora of the palatine tonsils and in the large intestine; the indices of the immunological status of patients with tonsillites; to establish the drug response rate of a simultaneous use in a course of multimodality therapy of tonsillitis of bifidobacteria-containing probiotics. Research methods: general clinico-laboratory; microbiological, immunological, statistical. Equipment: anaerostat, thermostat, luminescence microscope, microscope, centrifuge. The leading causative agents of tonsillites and their associales have been established, it has been demonstrated that tonsillites develops against a background of disturbed microbiocenosis of the mucous tunic of the palatine tonsils and the cavity of the large intestine and a formed secondary immunodeficiency condition, the humoral and cellular components of the systemic immunity; the drug response rate of a simultaneous use of bifidumbacterin locally and bifiform - perorally in the multimodality treatment of tonsillitis. It is demonstrated for the first time that the development and course of an inflammatory process of the the palatine tonsils is accompanied with disturbances of microbiocenosis (formed dysbacteriosis) of this biotope at the expense of the elimination or a marked deficit of autochthonous obligate (Bifidobacteria, Lactobacteria, Streptococcus salivarus, propionic acid bacteria). The extent of introduction: in the work of the infectious unit of the Regional Clinical Hospital of the City of Chernivtsi; at lecture courses, while conducting practical, seminar classes. The sphere (branch) of application: microbiology, infectology, otorhinolaryngology.