Yanovska V. The biological properties of enterococci and their role in the urinary tract infections

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004381

Applicant for

Specialization

  • 03.00.07 - Мікробіологія

02-07-2009

Specialized Academic Board

Д 64.618.01

State Institution "I.Mechnikov Institute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine"

Essay

Object of research: strains of enterococci isolated from urine of patients with inflammatory diseases of urinary tract, from stool of healthy children and children with perinatal pathology. Research objective: on the basis of studying of features of isolation enterococci, definitions of their biological properties to improve bacteriological diagnostics and use of antibiotics for treatment of different contingents of patients with infections of urinary tract. Research methods: bacteriological, genetic, statistical. Equipment: semi-automated analyzer; Densi-La-Meter; thermocecler; Incubator. The spectrum of antibiotic resistance of enterococci isolated from different contingents of patients has been determined; The antibiotics which can be choice preparations for treatment of infections urinary tract at different contingents of patients has been determined; It was isolated two vancomycin-resistant strains with type of resistance VanA. One vancomycin-resistant strain has been deposited. Introduction degree: The methodical recommendations; The circular. Has been shown differences of levels and profiles antibiotic resistant of enterocci depending on their kind and an origin. For the first time in Ukraine were selected two vancomycin-resistant E.faecium with the VanA resistance type from urine of patients of a surgical profile with hospital infection of urinary tract that has been defined by PCR. For the first time in Ukraine was established a considerable part of enterococci among hospital strains of with high level resistance to aminoglycoside. Sphere (branch) of use: public health services.

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