Rudenko S. Antimicrobial and pharmacological activity of quinoline heterocyclic salts, which contains amyno suger fragments

The thesis deals scrining and study of a perspective antimicrobial quinoline heterocyclic salts with amyno suger fragments. A biotop pathogenes of the bronchopneumonic system was determined and char in patients with an obstructive bronchitis. The levels of antimicrobial activity and influence spectrum of museum and clinical microorganisms cultures of 4, 5, 17, 20 groups derived from aminosaccharoquinoline were analyzed. The presence of some analyzed compounds influence to the basic factors of disease-productivity of the pathogens that have clinical significance and vegetate in the respiratory tract biotope was proved. Their anti-adhesive, anti-lysozyme and anti-immunoglobulin activity was defined. As well as their ability to eliminate plasmids of enteropathogenicity and antibiotic resistance and also to prevent intermicrobe transmission of R-plasmids in the conjugation process was denoted. Acute and chronical toxicity, coagulate effects and allergenic/desensitizing states of quinoline compounds were explored.