Yaroschenko V. Design and synthesis of polyfluoroalkyl-containing purines and their isosteres

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004655

Thesis Registration Form

0409U004655.pdf

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

15-09-2009

Specialized Academic Board

Д 26.001.25

Taras Shevchenko National University of Kyiv

Essay

The thesis is devoted to the design and synthesis of the purines and purine isosteres bearing the polyfluoroalkyl-containing substituents in the 2- and 6-positions, as potential inhibitors of the adenosine deaminase and inosine 5'-monophosphate dehydrogenase. During the course of pyridine and pyrimidine annulation studies involving cyclocondensation with aminoheterocycles, we have investigated the formation of Rf-containing purine and purine isosteres such as 1-desazapurines, 7-desazapurines, 1,7-desazapurines and 4-thiapurines by coupling various Rf-containing 1,3-CCC- and 1,3-CNC-biselectrophiles with the means of electron-rich aminoheterocycls.

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Files

aref.doc

diss.doc

diss.doc

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