Gudz V. Pathogenesis violation's mechanisms of blood coagulation system, peroxydation of lipids and antyoxydant system in the patients with acute hepatitis B and their correction.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004706

Thesis Registration Form

0409U004706.pdf

Applicant for

Specialization

  • 14.01.13 - Інфекційні хвороби

24-09-2009

Specialized Academic Board

Д 26.614.01

State Institution "The L.V. Gromashevsky Institute of epidemiology and infectious diseases of NAMS” of Ukraine"

Essay

The dissertation is devoted to the questions of pathogenesis of acute hepatitis B (AHB). We have examined of 159 patients with different forms of AHB. We determined, that high activity of LP is a result of lower activity of antioxidant ferments and has negative influence on hemostasis' system. Peculiarities of thrombocytes part of hemostasis, that depend on period and form of AHB were shown. Prolonging of time before coagulation's onset, coagulation blood time, decreasing of blood density, increasing of blood fibrinolytick activity are determined in the patients with severe AHB. Interrelation between indexes of blood coagulation system and violations in system LP/AOS, period and form of AHB. In order to correction of such breaches inductor of endogen interferon amyxin IC and hepatoprotector glutargin were used. Positive clinical, antioxidant, hypoammonic effect of such drugs' combination were noted.

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Files

Автореферат.doc

Диссертация собранная.doc

Диссертация собранная.doc

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