Korynevska A. Mechanisms of cytotoxic activity of landomycin E towards tumor cells in vitro.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004993

Thesis Registration Form

0409U004993.pdf

Applicant for

Korynevska Alla Venedyktivna

Specialization

14.01.07 - Онкологія

Date of defense

14-10-2009

Specialized Academic Board

Д 26.155.01

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Essay

The thesis is devoted to a study of the mechanisms of cytotoxic properties towards a wide range of mammalian tumor cell lines of the anthracycline-related angucycline landomycin E (LE).Apoptotic cell death induced by LE was further confirmed by caspase-(3 and -7) dependent cleavage of PARP-1, profound intracellular oxidative stress and by intensive mitochondrial membrane depolarisation. LE is only a weak substrate for P-gp and MRP1 (up to 2.5 times less sensitivity to the tumor cell lines with MDR comparatively to the wild type of cell lines), and is not transported by BCRP.

Thesis supervisor

Stoika Rostyslav Stepanovych

Official opponents

Матишевська Ольга Павлівна
Фільченков Олексій Олексійович

Files

doc_Korynevska.doc

АВТОРЕФЕРАТ з ТИТ.doc

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