Gyrin V. Immune system state of children with newly established type 1 diabetes mellitus in the presence of persistent Coxsackie B virus infection.

Dissertation deals with study of the role of persisting Coxsackie B virus infection in genesis of immune disturbances in children with newly established type 1 diabetes mellitus and search for immunomodulating action of antioxidant therapy. 112 ambulatory or hospital patients with type 1 diabetes mellitus aged 4-12 years and 30 relatively healthy children were examined. In the majority of children with newly established type 1 diabetes mellitus antibodies to Coxsackie B viruses have been determined, titers of which increased, which is indicative of persisting virus infection. Its course depending on the level of circulating antibodies has been accompanied with progressive decrease of C-peptide content in peripheral blood as well as enhancement of hyperglycemia and increase of glycosylated hemoglobin concentration. Marked disturbances of immune indices, the level of which depends on antibody titer to Coxsackie B viruses, have been revealed in the presence of C-peptide positive clinically apparent type 1 diabetes mellitus. Autoimmune responses are accompanied with activation of lipid peroxidation which is manifested in elevation of the blood content of the final product of lipid peroxide oxidation - malonic dialdehyde as well as increase of the amount of polyunsaturated fatty acids in blood plasma of patients with type 1 diabetes mellitus. Improvements in metabolic process clinical manifestations and immune system disturbances have been established during long-term usage of quercethin antioxidant along with intensive insulin therapy.