Pozur V. The immunomodulating effects of peptidoglycan Staphylococcus aureus WOOD 46 under the tumor grows.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U005672

Thesis Registration Form

0409U005672.pdf

Applicant for

Pozur Valentina

Specialization

03.00.09 - Імунологія

Date of defense

15-12-2009

Specialized Academic Board

Д 26.001.14

Taras Shevchenko National University of Kyiv

Essay

The thesis is devoted to examination of immunomodulating and antineoplastic properties of peptidoglycan Staphylococcus aureus Wood 46 under application alone and as a component of anticancer vaccine. The features of influence of peptidoglycan on oxidative metabolism of natural immunity effectors (monocytes, macrophages, neutrophils), cytotoxic activity of mononuclear splenocytes (against different target cells) and viability of tumor cells of different histogenesis in vitro were first investigated. It was shown that the peptidoglycan has immunomodulatory, antitumor and anti-metastatic properties. Efficiency of application of peptidoglycan as a antineoplastic agent was first proved in vivo experimental. Anticancer vaccine has developed with use of cancer cells treated with peptidoglycan. The comparative investigation of immunomodulatory and antitumor effects, caused both peptidoglycan used alone and as a part of antitumor vaccine, was carried out on the different experimental tumor growth models. The finding of investigation indicates that peptidoglycan could be considered as a perspective adjuvant in anticancer vaccines due to its ability to activate of anti-cancer immunity to provide forming of immunity against Staphylococcus aureus for prophylaxis of staphylococcus etiology infections.

Thesis supervisor

Potebny G.P.

Official opponents

Бичкова Ніна Григорівна
Орел Валерій Еммануїлович

Files

Автореферат Позур--КИЇВСЬКИЙ НАЦІОНАЛЬНИЙ УНІВЕРСИТЕТ.doc

Автореферат Позур--автореферат.doc

Дисертація. Позур--3.1..doc

Дисертація. Позур--3.2..doc

Дисертація. Позур--3.3..doc

Дисертація. Позур--3.4..doc

Дисертація. Позур--3.5.doc

Дисертація. Позур--3.6..doc

Дисертація. Позур--ВИСНОВКИ.doc

Дисертація. Позур--МІНІСТЕРСТВО ОСВІТИ І НАУКИ УКРАЇНИ.doc

Дисертація. Позур--РОЗДІЛ 1.doc

Дисертація. Позур--РОЗДІЛ 2.doc

Дисертація. Позур--РОЗДІЛ 4.doc

Дисертація. Позур--СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ.doc

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