Golovach N. Organocatalytic asymmetric synthesis and transformations of beta-trifluoromethyl-beta-aminoketones.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U000599

Thesis Registration Form

0410U000599.pdf

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

25-02-2010

Specialized Academic Board

Д 26.217.01

Institute of Organic Chemistry NAS of Ukraine

Essay

The investigation of organocatalytic asymmetric reaction of trifluoromethyl ketimines with carbonic compounds and the developing a facile and efficient synthetic access to chiral trifluoromethylsubstituted beta-aminoketone derivatives - 4-amino-4-aryl-5,5,5-trifluoro-2-pentanones. Based on quantum-chemical study of mechanism of the asymmetric L-proline-catalyzed reaction of aryl trifluoromethyl ketimines with acetone. It was show that beta-aminoketones are unique building blocks for the synthesis of chiral pyridines, pyrimidines, oxazines, tiazines, pyrolizines and diazepines.

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Files

Дисертація.doc

автореферат.doc

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