Kupsha E. Morphologic and functional changies in mice liver under prolongated ingestion of small lead doses in organism alha-tocoferol and "Erbisol" influencies on its.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U002105

Thesis Registration Form

0410U002105.pdf

Applicant for

Specialization

  • 14.03.09 - Гістологія, цитологія, ембріологія

07-04-2010

Specialized Academic Board

Д 52.600.02

Essay

The dissertation is devoted to study morphologic and functional displays of compensatory, adaptive and injury processes in white mice liver under prolongated influence of small lead doses and its correction by means tocoferol and "Erbisol". Using modern methods, such as electron microscopy, morphometry is established that toxic lead effects direct on the cellular targets, causing destruction of erythrocytes, endothelial cells, hepatocytes membranes. Application of tocoferol causes membrane protective effect of the hepatocytes mitochondria. Administration of "Erbisol" protects erytrocytes, endothelial cells membranes and causes immunomodulatory effect on the macrophages, providing better safety hepatic structures.

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