Chekalska N. Hormone and methabolic disturbances in insulin resistance syndrome in postmenopausal women and methods of their correction

Object of study: insulin resistance (IR) syndrome in menopausal women. Aim of the study: examine interrelations of hormonal and metabolic changes in woman with menopausal metabolic syndrome (MMS) and pathogenetic background of their correction with hormone replacement therapy (HRT) and insulin sensitizer metformin. Methods of investigation and devises: clinical, instrumental, anthropometrical, biochemical, radio immune, statistical methods; automatic analyzers STRATEC SR300, BioSystems A25, BioSystems Celly70. Theoretic and practical results: the association have been established of IR, SHBG level, abdominal obesity, lipid profile disorder, and androgenization in estrogen supplying decrease conditions. Intensification positive influence of comibined metformin and HRT therapy was revealed towards indices of androgenisity, IR, SHBG level, obesity, lipid profile. The results of the study will contribute to increase of efficacy of early diagnostics, prophylactics and management of MMS. The data background applying of the proposed complex of indices in diagnostics and treatment of MMS using HRT and metformin. Novelty: for the first time, peculiarities of hormonal and metabolic status in women with MMS comparing with healthy menopausal woman and in woman of reproductive period were estabished. Recommendations concerning clinical and laboratory investigation and treatment of women with MMS by transdermal HRT and metformin were developed. Degree of introduction: The results of study are used in clinical practice of the Institutions were the competitor is working and were the work was carried out. 3 declaration patents were issued under the No 41876, 42247, 43692. Sphere of application: endocrinology, gynecology.