Object: normal bone tissue and bone disorders in men of different age, bone tissue of intact male rats at reproductive age and animals with surgical castration (orchectomy). Aim: to identify the risk factors for bone loss, to improve diagnosis and treatment of osteoporosis in men of different age based on the study the structural-functional state of bone. Methods: clinical, anthropometric, densitometry, experimental modeling, statistical. For the first time in Ukraine the experimental model was done in male rats with osteoporosis due to hypogonadism, which reflects the violation of structural-functional state of bone in the presence of androgen deficiency. For the first time in Ukrainian men population the structure-functional state of bone according to ultrasound densitometry and dual x-ray absorptiometry were studied. First the risk factors and their influence on structural-functional state of bone in men of different age were identified. For the first time in Ukraine, age changes of hormonal status in men and the connection between androgens level, anthropometric parameters, the presence of clinical features of hypogonadism and structural-functional state were examined. For the first in Ukrainian men population dynamic of bone loss depending on age and testosterone level was estimated. The effectiveness of alendronate with calcium and vitamin D in treatment of men was studied and the differentiated approach to prevention and treatment of osteoporosis was offered. Proposed, scientifically substantiated and put into practice the treatment of clinical manifestations of hypogonadism with using nootropic agent Noophen in men middle age. For the practical using the diagnostic criteria the violation of structural-functional state of bone in men were proposed that allows recommending it during the mass surveys to detect osteoporosis and complex preventive measures. Proved that the leading risk factors bone loss in men age, body mass index, level of sex hormones in serum. Determination of risk factors that contribute the bone loss in men enables early detection of osteoporosis and effective solution for prevention. Study the hormone status of men in different age and establish the connection between the level of androgen and structural-functional state allowed to allocate risk of osteoporosis and its complications. Application of the proposed new schemes scientifically based prevention and treatment of structural-functional state of bone vegetovascular and psychical disorders like clinical manifestation of hypogonadism in men will help reduce the severity of vertebral pain, prevent bone loss, reduce the risk of fractures and improve quality of life. Knowledge the dynamics of bone loss depending on age and level of total testosterone, help carry out prophylactic measures to osteoporosis in men at risk, as was shown that the more rapid bone loss for the year are in men with low testosterone (compared with eugonadal men the same age). Experimental model of osteoporosis due to surgical castration (orchectomy) can be used to study mechanisms preventing the bone loss, as well as evaluating the effectiveness of drugs in the treatment of this pathology. All the above will improve the quality health care to men of different age in violation the structural-functional state of bone. The results are used in lectures at the Department of Gerontology and Geriatrics National Medical Academy of Postgraduate Education named P.L. Shupika, Health Ministry of Ukraine, information and training courses "Diagnosis and treatment of osteoporosis", cycle of conferences and seminars for school practitioners from different regions of Ukraine "Modern principles of diagnosis, prevention and treatment of musculoskeletal system" and "Menopause, andropause and disease of musculoskeletal system". Applied research results into clinical practice in the Institute of Gerontology of the Academy of Medical Sciences of Ukraine, National Medical Academy of Postgraduate Education named P.L. Shupika, Ukrainian medical center of the problems of osteoporosis, Kharkiv Medical Academy of Postgraduate Education of Health of Ukraine. Traumatology and Orthopedics.
