Kysmenko E. Circadian rhythm restoration of some haemopoiesis characteristics and an immunity after radiation exposure.

Refereed dissertation is dedicated to the study of the specifics of postradiation circadian rhythm and immunity restoration as a function of individual organism response to immobilization stress. The discrepancies of animal haemopoiesis characteristics with respect to type of reactivity to immobilization stress have been found out, which resulted in separating animals into two groups- hyporeactive and hypereactive. circadian rhythms of animals belonging to different activity groups as well as dynamic of circadian rhythm postradiation restoration of blood cell production and immunity of animals in order to determine their role in individual and group radiosensitivity have been studied. The influence of response type of haemopoiesis characteristics on the duration of postradiotional circadian rhythm blood creation restoration was discovered: hypereactive animals have had more higher degree of pancytopenia in comparison with hyporeactive animals. It was shown that effect of ionizing radiation in sublethal dose (4.0) has different influence on the shifts of haemopoiesis circadian rhythm and depends on exposure time to radiation and animals reactivity: destructive effects of radiation on lymphopoesis among hyporeactive rats exposed to 20:00 have been minimal. Estimation of immunity of rats with the different types of reactivity exposed in different time of 24 hours cycle has shown deep depression of immune system in hypereactive animals exposed at 8:00 in comparison with hyporeactive rats exposed at 20:00. The relationship between radiosensitivity and type of rats response on psychoemotional stress influence haves been discovered.