Sabirova T. Comparative description structural components of zoo- and phytopathogenic rhabdoviruses

Dissertation is devoted to the study of structural components of rhabdoviruses. It is the objects of researches to phytopatogenic rhabdovirus curly potato dwarf virus (CPDV) and viruses contaminating a man and animals viruses of vesicular stomatitis virus (VSV) and rabies virus (RV). At comparison the polypeptide composition of these rhabdoviruses it is shown, that they have similar value on the molecular the masses. A serologically relationship protein is exposed with molecular mass 43 kDa in composition the structural proteins CPDV, VSV and RV. Coming from the results of immunological researches on the exposure of antigen cognation of structural proteins of phytorhabdovirus CPDV and rhabdoviruses vertebrate VSV, was shown ability of antibodies specific to vegetable rhabdovirus CPDV to neutralize infectiousness of vesicular stomatitis virus in the culture animal cells. Finding testify to the prospect of researches in relation to the phytorhabdovirus CPDV application for diagnostics of vertebral rhabdoviruses. On the basis of indirect variant of immune-enzyme assay is shown possibility of the use of phytorhabdovirus CPDV for the indication to antibodies of specific to the rabies virus. In addition, CPDV and VSV, as well as other rhabdoviruses, are contained in the structure the carbohydrates and lipids, chemical organization, which is fully determined by cellular enzymes, providing the synthesis, transference and joining of the proper components. Authentication of carbohydrates and lipids showed that a phyto- and rhabdoviruses human and animals in a number of cases are contained by some identical carbohydrates and fat acids, that, possibly, reflects the single evolutional program of development of these viruses.