Dovgyj V. Immune and metabolic malfunctions in children with urticaria medicamentosa and their correction

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U006130

Thesis Registration Form

0410U006130.pdf

Applicant for

Specialization

  • 14.03.08 - Імунологія та алергологія

04-11-2010

Specialized Academic Board

Д 11.600.04

Donetsk National Medical University

Essay

The thesis colligates the data of a complex clinico-immunologic and bio-chemical examination of 192 patients with urticaria medicamentosa (UM). Patients with UM demonstrated malfunctions of systemic immunity humoral component: increase in CIC (circulation immune complex) concentration mainly at the cost of the most pathogenic medium-molecular and micro-molecular fractions, disimmunoglibulinemia. Patients with acute form of UM showed increase in the levels of proinflammatory cytokine (IL-1?, IL-2 and TNF? (tumor necrosis factor)) and disbalance of anti-inflammatory (IL-4) cytokine in blood - the majority of patients examined with alergic processes on skin.showed growth of its level. It has been ascertained that build-up of "middle molecules", metabolites of lipid peroxidation against the background of significant decrease in activity of antioxidant defense system ferments occurs in the patients examined. The degree of diagnosing bio-chemical rate abnormalities was positively correlated with the spread of acute UM. Inclusion of reamberin and atoxil into the treatment complex for children with acute UM has been pathogenetically validated. Appropriateness of carrying out immunorehabilitation of convalescents under secondary immunodeficiency with the help of polyoxidonium, and for those patients who have had acute UM with dysfunctional biliary tract disorders -cinarix, has been indicated.

Read more

Files

4.10..doc

Довгий дисер для печати--АНАЛІЗ ТА ОБГОВОРЕННЯ ОТРИМАНИХ РЕЗУЛЬТАТІВ.doc

Довгий дисер для печати--ВИСНОВКИ.doc

Довгий дисер для печати--Вступ.doc

Довгий дисер для печати--Огляд.doc

Довгий дисер для печати--РОЗДІЛ 2.doc

Довгий дисер для печати--РОЗДІЛ 3.doc

Довгий дисер для печати--РОЗДІЛ 5.doc

Довгий дисер для печати--РОЗДІЛ 6.doc

Довгий дисер для печати--РОЗДІЛ 7.doc

Довгий дисер для печати--Розділ 4.doc

Довгий дисер для печати--Список літератури.doc

авто-титул.doc

Similar theses

0521U101940

Hayduchok Ihor H.

Immunopathological syndromes in patients with systemic autoimmune diseases: immunopathogenesis and patient surveillance

0421U103550

Aikian Artem Z.

The role of M1 and M2 macrophage phenotypes in the immunopathogenesis of breast adenocarcinoma in the presence or absence of metastases in regional lymph nodes

0521U101728

Svitlana O. Zubchenko

Allergic diseases and chronic Epstein-Barr virus infection: pathogenesis, diagnostic approaches and therapeutic tactics of patient management

0421U102413

Lomikovska Marta Pavlivna

Immunopathogenesis of infectious reactive arthritis in the background of activated obligate infections (Chlamydia trachomatis and Epstein-Barr virus), patient surveillance

0421U102424

Horbal Natalya Myronivna

Features of the immune response in patients with systemic connective tissue diseases and reactivated herpes simplex virus type 1 infection and their management