Pridma S. New aminoalcohols and sulfonamides based on cage amines. Synthesis, structure and properties

The objects is synthesis and chemical properties of new biologically active derivatives of cage amines containing sulfonamide and aminoalcohol fragment. The purpose of work - development of the methods of synthesis of new practically useful derivatives of cage amines. Меthods - organic synthesis, NMR 1H, 13С spectroscopy, DEPT, experiments on homonuclear (COSY, NOESY) and heteronuclear correlation (HMQC, HMBC), IR-spectroscopy, mass-spectrometry, TL and column chromatography, X-ray and elementary analysis. Results - The synthesis of new amino alcohols containing cage fragments by aminolysis of glycidyl ethers and glycidylsulfonamides carried out. The effect of the carbon cage nature and its distance from the reaction center on the direction of reaction with epichlorohydrine is established. Sulfonamides with two cage fragments have been synthesized. The regularities of chemo- and regioselective epoxide ring opening in reactions glycidylsulfonamides and their epoxy derivatives with amines have been established. Criteria for classifying signals in the 1H NMR spectra of amino alcohols is developed. Substances with significant neurotrophic activity were found among the synthesized compounds. Area of application - organic chemistry.