Novokhatnia A. Pathogenetic peculiarities of ulcerogenesis factors formation in patients with Нelicobacter pylori-associated duodenal ulcer and accompanying chronic bronchitis.

The research is aimed on reveal of ulcerogenesis factors and their peculiarities in young persons with combined pathology - duodenal ulcer and chronic bronchitis, and also efficacy evaluation of melatonin preparation in complex treatment of such patients. Basing on investigation of health-related quality of life, concentration of melatonin, cytokines (tumor nectosis factor-?, interleukin-1?, interleukine-4), nitric oxide, determining parameters of regional blood circulation it was proved a prominent role of melatonin in formation of oxidative stress, immune deviations and endothelial dysfunction as factors of ulcer formation. Introduction of melatonin into standard scheme of antihelicobacter therapy of patients with Helicobacter pylori-positive duodenal ulcer, especially on background of accompanying chronic bronchitis, significantly speeds-up the remission and increases the heeling quality of ulcers. This is accompanied by normalization of cytokine system, oxidative stress and endothelial function indices, parameters of health-related quality of life.