Yarema N. Clinic-pathologic peculiarities of the antioxidant therapy in the complex inflammatory arthritis treatment for children

The dissertation discusses the optimization therapy of rheumatoid and reactive arthritis in children using ? -3 polyunsaturated fatty acids (epadol) and vegetable origin medications (lipophil complex of Wild Rose fruit and Silubum marianum). The results of the research of the state of the cellular and humoral immunity in rheumatoid and reactive arthritis patients de-pending on the activity degree process are presented. The influence of the state of peroxide lipid oxidation and antioxidant protective system activity on the ultrastructure of lymphocyte biological membranes in children is researched. The interconnections of the indi-ces of peroxide lipid oxidation and antioxidant protective system activity with the clinical and immunological indices in children with rheumatoid and reactive arthritis are analyzed. The influence of the common treatment for juvenile rheumatoid arthritis and the complex treatment with “Epadol” and dietetic prod-ucts (lipophil complex of Wild Rose fruit and Silubum marianum) on the dynamics of the clinical indices and the metabolic indicators of the connective tissue is researched. The common treatment for juvenile rheumatoid arthritis with “Epadol” and dietetic products (lipophil complex of Wild Rose fruit and Silubum marianum) is proved to have the positive influence on the indices of peroxide lipid oxidation and antioxidant protective system activity, the indices of the cellular and humoral immunity, the cytokine profile, and the lymphocyte ultrastructure in children with rheumatoid and reactive arthritis.