Kutcobina N. Improvement of diagnosis and prognosis of helicobacter-associated gastroduodenal pathology in children.

An object - gelikobakter-associated gastro-duodenal pathology for children. purpose - to promote efficiency of diagnostics and prognostication of chronic gastro-duodenal pathology for children on the basis of study of imunogenetichnikh conformities to law of its forming.;iaoiae - zagal'noklinichniy, psikhometrichniy, genotipuvannya, immunological, laboratory instrumental, statistical.; results - first from positions of clinical epidemiology on the basis of statistically reliable results multivariable analysis certainly factors of risk of development and the dynamics of morbidity is traced on gelikobakter-associated gastro-duodenal pathology for the children of the Tchernivtsi area; first by the method of polimeraznoy chain reaction the genetic structure of gelikobakteriozu is certain among children with gastro-duodenal pathology, the regional distributing of genes of pathogenicity of Helicobacter of pylori is conducted, distributing features are set pathogenic genotypes of exciter at the different diseases of gastro-duodenal area for children, comparative topological description of the bacterial sowing of stomach is given by the different genotypes of pyloric gelikobakteriy; it is first studied vzaemozv''yazki between the indexes of cellular, gumoral'noy and fagocitarnoy lanocs of the immune system of children, patients, on gelikobakter-associated gastro-duodenal pathology, depending on the genotype of exciter and phase of disease; set by the determined toksigennimi cultures of feature of immune answer of organism depending on the genotype of pyloric gelikobakteriy; it is confirmed, that the toksigenni cultures of Helicobacter of pylori draw more expressed damaging operating on the mucus shell of gastro-duodenal area and pov''yazani with the maximal increase of kislotoutvorennya in a stomach.