Krylova O. Pathogenetic Grounding and Clinical Effectiveness of Non-steroid Anti-inflammatory Preparations in Complex Therapy of Generalized Periodontitis Patients

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U004451

Thesis Registration Form

0411U004451.pdf

Applicant for

Specialization

  • 14.01.22 - Стоматологія

10-07-2011

Specialized Academic Board

Д 64.600.02

Essay

In the dissertation it is defined the pathogenetic role of abnormalities of lipids peroxide oxidation (LPO) - antioxidant protection (AP), disbalance of pro- and anti-inflammatory cytokines of mouth cavity in interconnection with clinical disbalances in the development of generalized periodontitis (GP) in chronic course of initial I and I-II rate of severity. It is worked out the treatment method of GP in chronic course which presupposes the use of non-steroid anti-inflammatory drugs (NSAID) locally, which are injected durably as suspension with the help of periodontal cups and additionally inside which favors inflammation elimination, remission of pathologic process. It is given the grounding of non-steroid anti-inflammatory drugs (NSAID) (non-selective inhibitor of cyclooxygenase (COX) - diclofenac, selective inhibitor COX - 2 - nimesulid as well as specific inhibitor COX - 2 celekoksib) use and the assessment of their effectiveness. The investigations proved the ability of diclofenac, nimesulid, celekoksib in different extent to lower the level of LPO and to intensify AP, to normalize cytokine regulation, which hinders inflammation, tissues destruction and betters repair conditions.

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Files

aref.doc

dis--АНАЛІЗ І УЗАГАЛЬНЕННЯ ОТРИМАНИХ РЕЗУЛЬТАТІВ ДОСЛІДЖЕННЯ.doc

dis--ВИСНОВКИ.doc

dis--ВСТУП.doc

dis--РОЗДІЛ 1. ОГЛЯД ЛІТЕРАТУРИ.doc

dis--РОЗДІЛ 2. ОБ`Єкт та методи дослідження.doc

dis--РОЗДІЛ 3 та 3.1.doc

dis--РОЗДІЛ 3 та 3.1.doc

dis--РОЗДІЛ 3.2 та 3.3 ПОЛ и цитокины 2.doc

dis--СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ.doc

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